Dr. Karolina A. Aberg was awarded a Small Research Grant (R03) from the National Institute of Mental Health, entitled “Mediators of Methylomic Profiles in 1500 Schizophrenia Cases and Controls”. This study takes advantage of our methylome-wide association study data that we recently published and additional phenotype and extensive genotype information is available. For this project we propose a set of novel analysis that aims to find methylation markers and further improve our understanding of the role played by methylation in SZ pathogenesis. This goal will be achieved through data integration. For this purpose we will first conduct MWAS of environmental mediators and perform methylation quantitative trait locus (meQTL) analyses exploring potential regulatory differences between SZ cases and controls. In addition to the data that is generated by performing additional MWAS and meQTL analyses, we will also include other data sets such as GWAS and genome-wide mRNA expression that are directly related to SZ or of relevance for brain function.