Dr. Robin F Chan was awarded a prestigious 2019 NARSAD Young Investigator Grant (Brain & Behavior Research Foundation) to use leading-edge technologies to investigate how epigenetic markers influence gene expression in major depressive disorder. Using the latest in CRISPR-Cas9 tools, Dr. Chan will directly modify specific DNA methylation sites linked to depression and test their functional effects. By using a cell culture model of hESC-derived neurons, the effects of these DNA methylation markers can be tested in a manner more closely resembling human brain. Hence this research has implications for developing new forms of treatment for depression.