Dr. Robin F Chan was awarded a Local SMRT Grant (Pacific Biosciences) to evaluate long-read sequencing technology for detected novel DNA methylation modifications in human brain. Recent evidence suggests that the novel DNA modification, N6-methyl-2’-deoxyadenosine (m6dA), plays important roles in behavioral responses. However, current methods of detecting m6dA in DNA are often subject to biases or lack fine resolution. Therefore, Dr. Chan proposes to use SMRT sequencing from PacBio to determine the location and properties of m6dA in human brain for the first time.