Center for Biomarker Research & Precision Medicine School of Pharmacy

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Research overview

Psychiatric and substance use disorders
Biomarkers and precision medicine
DNA methylation
Omic investigations as a tool
   

Grants

Since its inception in 2006, BPM has been awarded more than 20 competitive research grants where BPM faculty are principal investigator (PI) and more than 10 where BPM faculty are either co-investigators (Co-I) or co-sponsors (Co-S).

Completed

Selected Publications

Selected
van den Oord EJCG, Chan RF, Aberg KA. Successes and Challenges in Precision Medicine in Psychiatry. JAMA Psychiatry. 2018 Dec 1;75(12):1269-1270. PMID: 30422244 Aberg KA, Dean B, Shabalin AA, Chan RF, Han LKM, Zhao M, van Grootheest G, Xie LY, Milaneschi Y, Clark SL, Turecki G, Penninx BWJH, van den Oord EJCG. Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples. Mol Psychiatry. Epub 2018 Sep 21. PMID: 30242228 Copeland WE, Shanahan L, Hinesley J, Chan RF, Aberg KA, Fairbank JA, van den Oord EJCG, Costello EJ. Association of Childhood Trauma Exposure With Adult Psychiatric Disorders and Functional Outcomes. JAMA Netw Open. 2018 Nov 2;1(7). PMID: 30646356 Han LKM, Aghajani M, Clark SL, Chan RF, Hattab MW, Shabalin AA, Zhao M, Kumar G, Xie LY, Jansen R, Milaneschi Y, Dean B, Aberg KA, van den Oord EJCG, Penninx BWJH. Epigenetic Aging in Major Depressive Disorder. Am J Psychiatry. 2018 Aug 1;175(8):774-782. Epub 2018 Apr 16. PMID: 29656664 Shabalin AA, Hattab MW, Clark SL, Chan RF, Kumar G, Aberg KA, van den Oord EJCG. RaMWAS: fast methylome-wide association study pipeline for enrichment platforms. Bioinformatics. 2018 Jul 1;34(13):2283-2285. PMID: 29447401 Aberg KA, Chan RF, Shabalin AA, Zhao M, Turecki G, Staunstrup NH, Starnawska A, Mors O, Xie LY, van den Oord EJ A MBD-seq protocol for large-scale methylome-wide studies with (very) low amounts of DNA. Epigenetics. 2017 Sep;12(9):743-750. Epub 2017 Nov 6. PMID: 28703682 Chan RF, Shabalin AA, Xie LY, Adkins DE, Zhao M, Turecki G, Clark SL, Aberg KA, van den Oord EJCG. Enrichment methods provide a feasible approach to comprehensive and adequately powered investigations of the brain methylome. Nucleic Acids Res. 2017 Jun 20;45(11):e97. PMID: 28334972 Clark SL, McClay JL, Adkins DE, Kumar G, Aberg KA, Nerella S, Xie L, Collins AL, Crowley JJ, Quackenbush CR, Hilliard CE, Shabalin AA, Vrieze SI, Peterson RE, Copeland WE, Silberg JL, McGue M, Maes H, Iacono WG, Sullivan PF, Costello EJ, van den Oord EJ. Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence. Alcohol Clin Exp Res. 2017 Apr;41(4):711-718. Epub 2017 Mar 24. PMID: 28196272 Hattab MW, Shabalin AA, Clark SL, Zhao M, Kumar G, Chan RF, Xie LY, Jansen R, Han LK, Magnusson PK, van Grootheest G, Hultman CM, Penninx BW, Aberg KA, van den Oord EJ. Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies. Genome Biol. 2017 Jan 30;18(1):24. PMID: 28137292 Aberg KA, McClay JL, Nerella S, Clark S, Kumar G, Chen W, Khachane AN, Xie L, Hudson A, Gao G, Harada A, Hultman CM, Sullivan PF, Magnusson PK, van den Oord EJ. Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults. JAMA Psychiatry. 2014 Mar;71(3):255-64. PMID: 24402055 Aberg KA, Liu Y, Bukszár J, McClay JL, Khachane AN, Andreassen OA, Blackwood D, Corvin A, Djurovic S, Gurling H, Ophoff R, Pato CN, Pato MT, Riley B, Webb T, Kendler K, O'Donovan M, Craddock N, Kirov G, Owen M, Rujescu D, St Clair D, Werge T, Hultman CM, Delisi LE, Sullivan P, van den Oord EJ. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry. 2013 Jun;70(6):573-81. PMID: 23894747 McClay JL, Adkins DE, Vunck SA, Batman AM, Vann RE, Clark SL, Beardsley PM, van den Oord EJ. Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure. Metabolomics. 2013 Apr 1;9(2):392-402. Epub 2012 Aug 26. PMID: 23554582 Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet. 2013 Apr 20;381(9875):1371-1379. doi: 10.1016/S0140-6736(12)62129-1. Epub 2013 Feb 28. Erratum in: Lancet. 2013 Apr 20;381(9875):1360. Erratum in: Lancet. 2013 Apr 20;381(9875):1360. PMID: 23453885 Adkins DE, Aberg K, McClay JL, Bukszár J, Zhao Z, Jia P, Stroup TS, Perkins D, McEvoy JP, Lieberman JA, Sullivan PF, van den Oord EJ. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. Mol Psychiatry. 2011 Mar;16(3):321-32. doi: 10.1038/mp.2010.14. Epub 2010 Mar 2. PMID: 20195266 McClay JL, Adkins DE, Aberg K, Stroup S, Perkins DO, Vladimirov VI, Lieberman JA, Sullivan PF, van den Oord EJ. Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics. Mol Psychiatry. 2011 Jan;16(1):76-85. doi: 10.1038/mp.2009.89. Epub 2009 Sep 1. PMID: 19721433

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